Plant cells absorb many important substances through a process called endocytosis. In plants, endocytosis is essential for nutrient uptake, passing on cellular signals and plant-microbe interactions. However, the vital nature of endocytosis makes it challenging to study using methods from classical genetics. Small molecules targeting this process are a good alternative for such studies but in plants, they are lacking. An international collaborative effort of scientists from several VIB Centers, Ghent University and the Free University of Berlin, coordinated by Prof. Jenny Russinova, found a new chemical that blocks endocytosis.